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5 MG
$80.58
25 MG
$345.00
About This Item
Empirical Formula (Hill Notation):
C20H17BrO5
CAS Number:
Molecular Weight:
417.25
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
$80.58
List Price$85.00Save 5%Web-Only Promotion
Check Cart for Availability
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Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
Brc1cc(ccc1)COc2c(c3[o][c](c(c(c3cc2)C)CC(=O)O)=O)C
InChI key
STHJGDCGBDTTHP-UHFFFAOYSA-N
Related Categories
Biochem/physiol Actions
DRAinh-A250 is an orally active, reversible, specific and potent inhibitor of Cl-/anion exchanger SLC26A3 (downregulated in adenoma; DRA). DRAinh-A250 inhibits fluid absorption in mice closed colonic loops but not in jejunal loops. It is nontoxic in cell culture.
an orally active, reversible, specific and potent inhibitor of Cl-/anion exchanger SLC26A3
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Peter M Haggie et al.
JCI insight, 3(14) (2018-07-27)
SLC26A3 (downregulated in adenoma; DRA) is a Cl-/anion exchanger expressed in the luminal membrane of intestinal epithelial cells, where it facilitates electroneutral NaCl absorption. SLC26A3 loss of function in humans or mice causes chloride-losing diarrhea. Here, we identified slc26a3 inhibitors
Chung-Ming Tse et al.
Cellular and molecular gastroenterology and hepatology, 7(3), 641-653 (2019-01-20)
SLC26A3 (DRA) is an electroneutral Cl-/HCO3- exchanger that is present in the apical domain of multiple intestinal segments. An area that has continued to be poorly understood is related to DRA regulation in acute adenosine 3',5'-cyclic monophosphate (cAMP)-related diarrheas, in which DRA
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