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SML2680

Sigma-Aldrich

ES24

≥98% (HPLC)

Synonym(s):

2-{2-[3-(5-nitro-2-furyl)-2-propen-1-ylidene]hydrazino}-2-oxoethylbenzene

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5 MG
$80.75
25 MG
$276.00

About This Item

Empirical Formula (Hill Notation):
C15H13N3O4
Molecular Weight:
299.28
UNSPSC Code:
12352200
NACRES:
NA.77

$80.75

List Price$85.00Save 5%
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Available to ship onMay 02, 2025Details

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

faint yellow to dark orange

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

Biochem/physiol Actions

ES24 is an Eeyarestatin 1 analog that blocks protein translocation in vitro and more effectively enhances Sec61-mediated Ca2+ leakage from Endoplasmic Reticulum (ER). Apparently ES24 keep Sec61 in open position allowing Ca2+ ions to move freely through the aqueous channel present. It causes cell-type-specific Ca2+-dependent cell death.
blocks protein translocation in vitro and effectively enhances Sec61-mediated Ca2+ leakage from Endoplasmic Reticulum (ER).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000094077
0000094078
0000081554

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Igor Gamayun et al.
Cell chemical biology, 26(4), 571-583 (2019-02-26)
Eeyarestatin 1 (ES1) inhibits p97-dependent protein degradation, Sec61-dependent protein translocation into the endoplasmic reticulum (ER), and vesicular transport within the endomembrane system. Here, we show that ES1 impairs Ca2+ homeostasis by enhancing the Ca2+ leakage from mammalian ER. A comparison

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