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SML2562

Sigma-Aldrich

Raphin1

≥98% (HPLC)

Synonym(s):

2-[(2,3-Dichlorophenyl)methylene]hydrazinecarboximidamide, N-(2, 3-Dichlorobenzylideneamino) guanidine, Rational inhibitor of a holophosphatase1

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5 MG
$85.00
25 MG
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About This Item

Empirical Formula (Hill Notation):
C8H8Cl2N4
CAS Number:
94023-67-3
Molecular Weight:
231.08
MDL number:
MFCD03653280
UNSPSC Code:
12352200
NACRES:
NA.77

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

SMILES string

Clc1c(cccc1\C=N\N=C(N)N)Cl

InChI

1S/C8H8Cl2N4/c9-6-3-1-2-5(7(6)10)4-13-14-8(11)12/h1-4H,(H4,11,12,14)/b13-4+

InChI key

WLTSTDGGFCQWTK-YIXHJXPBSA-N

Biochem/physiol Actions

Raphin1 is an orally available, brain penetrant, potent and selective inhibitor of protein phosphatase 1 regulatory subunit 15B (PPP1R15B; R15B). It does not inhibit PP1c. Raphin1 transiently decreases protein synthesis in cells. It is efficacious in mouse model of Huntington′s disease.
orally available, brain penetrant, potent and selective inhibitor of protein phosphatase 1 regulatory subunit 15B (PPP1R15B; R15B).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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