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SML2538

Sigma-Aldrich

KL-2

≥98% (HPLC)

Synonym(s):

N-(5-Chloro-2-methylphenyl)-4-(4-fluorophenyl)-2-hydroxy-4-oxo-2-butenamide

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5 MG
$84.83
25 MG
$287.00

About This Item

Empirical Formula (Hill Notation):
C17H13ClFNO3
CAS Number:
900308-51-2
Molecular Weight:
333.74
UNSPSC Code:
12352200
NACRES:
NA.77

$84.83

List Price$89.30Save 5%
Web-Only Promotion

Available to ship onApril 29, 2025Details

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC1=CC=C(Cl)C=C1NC(/C(O)=C/C(C2=CC=C(F)C=C2)=O)=O

Biochem/physiol Actions

Disruptor of SEC (super elongation complex)
KL-2 is a disruptor of the super elongation complex (SEC). KL-1 blocks the interactions of positive transcription elongation factorb (P-TEFb) and the SEC-scaffolding protein AFF4 resulting in decreased Polymerase II (Pol II) activity and production of Pol II-transcribed genes. KL-2 was shown to cause downregulation of heat shock genes, and was non-toxic and active in an animal model of cancer.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000067772
0000067773
0000061163

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Kaiwei Liang et al.
Cell, 175(3), 766-779 (2018-10-20)
The super elongation complex (SEC) is required for robust and productive transcription through release of RNA polymerase II (Pol II) with its P-TEFb module and promoting transcriptional processivity with its ELL2 subunit. Malfunction of SEC contributes to multiple human diseases

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