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SML2466

Sigma-Aldrich

OXFBD04

≥98% (HPLC)

Synonym(s):

3-(3,5-dimethylisoxazol-4-yl)-5-(hydroxy(pyridin-3-yl)methyl)phenol

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5 MG
$67.40
25 MG
$287.00

About This Item

Empirical Formula (Hill Notation):
C17H16N2O3
CAS Number:
2231747-03-6
Molecular Weight:
296.32
UNSPSC Code:
12352200
NACRES:
NA.77

$67.40

List Price$71.10Save 5%
Web-Only Promotion
Check Cart for Availability
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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC1=NOC(C)=C1C2=CC(C(O)C3=CN=CC=C3)=CC(O)=C2

InChI key

RFDVEAHRRMEOHK-UHFFFAOYSA-N

Biochem/physiol Actions

BRD4 inhibitor
OXFBD04 is a potent and selective inhibitor of BRD4(1) that inhibits interactions of BRD4with the RelA subunit of NF-κB. OXFBD02 inhibits proliferation of various cancer cell lines including leukaemia, breast, and renal cancer cell lines.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Laura E Jennings et al.
Bioorganic & medicinal chemistry, 26(11), 2937-2957 (2018-05-20)
Ligands for the bromodomain and extra-terminal domain (BET) family of bromodomains have shown promise as useful therapeutic agents for treating a range of cancers and inflammation. Here we report that our previously developed 3,5-dimethylisoxazole-based BET bromodomain ligand (OXFBD02) inhibits interactions

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