SML2400

LW106

>97% (HPLC)

• Synonym(s): (4-Amino-1,2,5-oxadiazol-3-yl)(1,3-dihydro-2H-isoindol-2-yl)-methanone oxime, (E)-(4-Amino-1,2,5-oxadiazol-3-yl)(isoindolin-2-yl)methanone oxime
• Empirical Formula (Hill Notation): C₁₁H₁₁N₅O₂
• CAS Number: 2116519-76-5
• Molecular Weight: 245.24
• UNSPSC Code: 12352200

Properties

• assay: >97% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O/N=C(C1=NON=C1N)/N2CC3=CC=CC=C3C2

Description

Biochem/physiol Actions

Indoleamine 2,3-dioxygenase 1 (IDO; IDO1) inhibitor with better in vivo antitumor efficacy than Epacadostat (INCB024360).

LW106 is an indoleamine 2,3-dioxygenase 1 (IDO; IDO1) inhibitor (IC50 = 13 nM) that effectively inhibits kynurenine production upon cellular IDO1 upregulation by IFNγ induction (50 ng/mL, 48 h) in HeLa cultures (IC50 = 1.57 μM) and prevents the antiproliferation activity of IDO1-positive DCs against co-cultured CD8+ T-cells (proliferation suppression = 67% with vehicle vs. 33% with 20 μM LW106). LW106 exhibits antitumor activity only in immunocompetent, but not athymic or IDO1-/-, mice, displaying better in vivo efficacy than Epacadostat (Lewis lung carcinoma/B16-F10 tumor suppression = 68%/65% with LW106 vs. 51%/50% with Epacadostat; 80 mg/kg/day i.p.).

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable