SML2344
SJB3-019A
≥98% (HPLC)
Synonym(s):
2-(Pyridin-3-yl)napthalo(-2,3-d)oxazole-4,9-dione
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About This Item
Empirical Formula (Hill Notation):
C16H8N2O3
CAS Number:
Molecular Weight:
276.25
UNSPSC Code:
12352200
NACRES:
NA.77
assay
≥98% (HPLC)
form
powder
color
white to very dark gray
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
potent USP1 inhibitor that induces ID1 degradation, upregulation of p21 and cytoxicity in K562 and other leukemic cell lines
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Helena Mistry et al.
Molecular cancer therapeutics, 12(12), 2651-2662 (2013-10-17)
Inhibitor of DNA binding 1 (ID1) transcription factor is essential for the proliferation and progression of many cancer types, including leukemia. However, the ID1 protein has not yet been therapeutically targeted in leukemia. ID1 is normally polyubiquitinated and degraded by
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