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SML2212

Sigma-Aldrich

RWJ 67657

≥98% (HPLC)

Synonym(s):

3-Butyn-1-ol, 4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl], 4-(4-Fluorophenyl)-2-(4-hydroxy-1-butynyl)-1-(3-Phenylpropyl)-5-(4-Pyridyl)imidazole, 4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol, JNJ 3026582

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5 MG
$78.02
25 MG
$271.00

About This Item

Empirical Formula (Hill Notation):
C27H24FN3O
CAS Number:
215303-72-3
Molecular Weight:
425.50
MDL number:
MFCD11840606
UNSPSC Code:
12352200
NACRES:
NA.77

$78.02

List Price$82.30Save 5%
Web-Only Promotion

Available to ship onApril 30, 2025Details

Request a Bulk Order

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

OCCC#CC1=NC(C2=CC=C(F)C=C2)=C(C3=CC=NC=C3)N1CCCC4=CC=CC=C4

InChI

1S/C27H24FN3O/c28-24-13-11-22(12-14-24)26-27(23-15-17-29-18-16-23)31(25(30-26)10-4-5-20-32)19-6-9-21-7-2-1-3-8-21/h1-3,7-8,11-18,32H,5-6,9,19-20H2

InChI key

QSUSKMBNZQHHPA-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

RWJ 67657 is an orally active, potent and selective inhibitor of p38α and p38β MAP kinases. RWJ 67657 inhibits the release of TNF-α and IL-1β from LPS induced blood mononuclear cells. It exhibits cardioprotective and anti-inflammatory activities in vivo.
orally active, potent and selective inhibitor of p38α and p38β MAP kinases

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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S A Wadsworth et al.
The Journal of pharmacology and experimental therapeutics, 291(2), 680-687 (1999-10-19)
Tumor necrosis factor-alpha (TNF-alpha), a cytokine secreted by activated monocytes/macrophages and T lymphocytes, has been implicated in several disease states, including rheumatoid arthritis, inflammatory bowel disease, septic shock, and osteoporosis. Monocyte/macrophage production of TNF-alpha is dependent on the mitogen-activated protein
S K Mathur et al.
The British journal of surgery, 77(4), 432-435 (1990-04-01)
Of 104 patients with portal hypertension who were subjected to oesophageal variceal sclerotherapy, gastric varices were seen in 81 (78 per cent) at endoscopy and 69 (74 per cent) at splenoportography. In 50 (48 per cent) patients gastric varices were
Ying-Ying Bai et al.
Stroke, 46(7), 1938-1946 (2015-06-06)
An immature vascular phenotype in diabetes mellitus may cause more severe vascular damage and poorer functional outcomes after stroke, and it would be feasible to repair damaged functional vessels using endothelial progenitor cell (EPC) transplantation. However, high glucose induces p38

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