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SML2210

Sigma-Aldrich

AubipyOMe

≥97% (NMR)

Synonym(s):

(SP-4-2)-dichloro(4,4′-dimethoxy-2,2′-bipyridine-kN1,kN1′)-Gold(1+), hexafluorophosphate(1-), [Au(4,4′-dimethoxy-2,2′-bipyridine)Cl2][PF6]

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5 MG
$105.00
25 MG
$423.00

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Available to ship onApril 29, 2025Details

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5 MG
$105.00
25 MG
$423.00

About This Item

Empirical Formula (Hill Notation):
C12H12AuCl2N2O2 · PF6
CAS Number:
1221591-26-9
Molecular Weight:
629.07
UNSPSC Code:
12352200
NACRES:
NA.77

$105.00

Available to ship onApril 29, 2025Details

Request a Bulk Order

assay

≥97% (NMR)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[Cl-][Au+3]1([N]2=C(C=C(C=C2)OC)C3=[N]1C=CC(OC)=C3)[Cl-].F[P-](F)(F)(F)(F)F

Biochem/physiol Actions

AubipyOMe is a potent inhibitor of tartrate resistant acid phosphatase (TRAP/ACP5), a metalloenzyme expressed in activated osteoclasts and in macrophages. AubipyOMe exhibited IC50 values of 1.3 μM for TRAP5a and 1.8 μM for TRAP5b and inhibited TRAP activity in murine macrophage and human lung tissue extracts.
Tartrate resistant acid phosphatase (TRAP/ACP5) inhibitor

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000201803
0000201804

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Shujun Yang et al.
Molecular medicine (Cambridge, Mass.), 30(1), 89-89 (2024-06-16)
Myocardial infarction (MI) leads to enhanced activity of cardiac fibroblasts (CFs) and abnormal deposition of extracellular matrix proteins, resulting in cardiac fibrosis. Tartrate-resistant acid phosphatase 5 (ACP5) has been shown to promote cell proliferation and phenotypic transition. However, it remains
Carian E Boorsma et al.
Scientific reports, 7(1), 12570-12570 (2017-10-05)
The enzyme tartrate resistant acid phosphatase (TRAP, two isoforms 5a and 5b) is highly expressed in alveolar macrophages, but its function there is unclear and potent selective inhibitors of TRAP are required to assess functional aspects of the protein. We

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