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SML2186

Sigma-Aldrich

Poloppin

≥98% (HPLC)

Synonym(s):

5-(4-Bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrole-2-propanoic acid, Polo protein-protein interaction inhibitor

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5 MG
$67.19
25 MG
$360.00

About This Item

Empirical Formula (Hill Notation):
C20H15BrF3NO2
CAS Number:
683808-78-8
Molecular Weight:
438.24
UNSPSC Code:
12352200
NACRES:
NA.77

$67.19

List Price$71.10Save 5%
Web-Only Promotion

Available to ship onMay 05, 2025Details

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

Storage temp.

2-8°C

SMILES string

OC(CCC1=CC=C(C2=CC=C(Br)C=C2)N1C3=CC=CC=C3C(F)(F)F)=O

InChI

1S/C20H15BrF3NO2/c21-14-7-5-13(6-8-14)17-11-9-15(10-12-19(26)27)25(17)18-4-2-1-3-16(18)20(22,23)24/h1-9,11H,10,12H2,(H,26,27)

Inchi Key

OCUKOJUZSNFVFQ-UHFFFAOYSA-N

Biochem/physiol Actions

Poloppin is a cell penetrant and potent inhibitor of mitotic Polo-like kinases (PLKs) that binds to the Polo-box domain (PBD) and prevents PLKs interaction with pSer/pThr phosphopeptide substrates. Poloppin induces mitotic arrest and apoptosis in cancer cells expressing mutant KRAS in 2D and organoid cultures. It also sensitizes mutant KRAS-expressing cancer cells to Crizotinib.
cell penetrant and potent inhibitor of PLKs that binds to the Polo-box domain (PBD) and prevents PLKs interaction with phosphopeptide substrates

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
0000041004
0000041005
0000031579

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Ana J Narvaez et al.
Cell chemical biology, 24(8), 1017-1028 (2017-08-16)
Mutations activating KRAS underlie many forms of cancer, but are refractory to therapeutic targeting. Here, we develop Poloppin, an inhibitor of protein-protein interactions via the Polo-box domain (PBD) of the mitotic Polo-like kinases (PLKs), in monotherapeutic and combination strategies to

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