Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

SML2180

Sigma-Aldrich

KEA1-97

≥98% (HPLC)

Synonym(s):

4,6-Dichloro-N-(4′-fluoro-[1,1′-biphenyl]-4-yl)-1,3,5-triazin-2-amine

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
$84.83
25 MG
$287.00

$84.83

List Price$89.30Save 5%
Web-Only Promotion

Available to ship onMay 02, 2025Details

Request a Bulk Order
Notify Me

Get notified when this item is ready to ship via email.

All Photos(1)

Select a Size

Change View
5 MG
$84.83
25 MG
$287.00

About This Item

Empirical Formula (Hill Notation):
C15H9Cl2FN4
CAS Number:
2138882-71-8
Molecular Weight:
335.16
UNSPSC Code:
12352200
NACRES:
NA.77

$84.83

List Price$89.30Save 5%
Web-Only Promotion

Available to ship onMay 02, 2025Details

Request a Bulk Order
Notify Me

Get notified when this item is ready to ship via email.

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC1=CC=C(C2=CC=C(NC3=NC(Cl)=NC(Cl)=N3)C=C2)C=C1

InChI

1S/C15H9Cl2FN4/c16-13-20-14(17)22-15(21-13)19-12-7-3-10(4-8-12)9-1-5-11(18)6-2-9/h1-8H,(H,19,20,21,22)

InChI key

DUROVTLUQOYUPH-UHFFFAOYSA-N

Biochem/physiol Actions

KEA1-97 is a Thioredoxin-Caspase 3 interaction disruptor. It was found to target lysine 72 of thioredoxin, inhibiting its interactions with caspase 3 and inducing apoptosis without affecting other thioredoxin activity. KEA1-97 induced apoptosis in breast cancer cells and treatment of immune-deficient SCID mice at 5 mg/kg ip impaired breast tumor xenograft growth.
Thioredoxin-Caspase 3 interaction disruptor; apotosis inducer

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Kimberly E Anderson et al.
ACS chemical biology, 12(10), 2522-2528 (2017-09-12)
Covalent ligand discovery is a promising strategy to develop small-molecule effectors against therapeutic targets. Recent studies have shown that dichlorotriazines are promising reactive scaffolds that preferentially react with lysines. Here, we have synthesized a series of dichlorotriazine-based covalent ligands and

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service