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SML2120

Sigma-Aldrich

Nifekalant hydrochloride

≥98% (HPLC)

Synonym(s):

6-[[2-[(2-hydroxyethyl)[3-(4-nitrophenyl)propyl]amino]ethyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione monohydrochloride

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5 MG
$64.88
25 MG
$230.00

About This Item

Empirical Formula (Hill Notation):
C19H27N5O5 · HCl
CAS Number:
130656-51-8
Molecular Weight:
441.91
MDL number:
MFCD00892243
UNSPSC Code:
12352200

$64.88

List Price$68.30Save 5%
Web-Only Promotion

Available to ship onMay 02, 2025Details

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assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CN1C(NCCN(CCO)CCCC2=CC=C([N+]([O-])=O)C=C2)=CC(N(C)C1=O)=O.Cl

InChI

1S/C19H27N5O5.ClH/c1-21-17(14-18(26)22(2)19(21)27)20-9-11-23(12-13-25)10-3-4-15-5-7-16(8-6-15)24(28)29;/h5-8,14,20,25H,3-4,9-13H2,1-2H3;1H

InChI key

YPVGGQKNWAKOPX-UHFFFAOYSA-N

Biochem/physiol Actions

Nifekalant is a pure potassium channel blocker and class III antiarrhythmic. It has been used to treat arrhythmias and ventricular tachycardia.
Potassium channel blocker, Antiarrhythmic agent, class III

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Sou Otuki et al.
Journal of electrocardiology, 50(3), 277-281 (2017-02-28)
Patients with repetitive ventricular tachyarrhythmias - so-called electrical storm - frequently require antiarrhythmic drugs. Amiodarone is widely used for the treatment of electrical storm but is ineffective in some patients. Therefore, we investigated the efficacy of stepwise administration of nifekalant
Takashi Tagami et al.
Resuscitation, 109, 127-132 (2016-08-29)
We evaluated the association between nifekalant or amiodarone on hospital admission and in-hospital mortality for cardiac arrest patients with persistent ventricular fibrillation on hospital arrival. This was a retrospective cohort study using the Japanese Diagnosis Procedure Combination inpatient database. We
Makoto Suzuki et al.
Journal of arrhythmia, 32(3), 186-190 (2016-06-30)
Ventricular tachyarrhythmias (VTs) are life-threatening events that result in hemodynamic compromise. Recurrence is common and may worsen a patient׳s clinical course despite appropriate treatment. This study aimed to examine the effectiveness of antiarrhythmic drugs for suppression of VTs. In this

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