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SML2056

Sigma-Aldrich

Pralmorelin trifluoroacetate salt

≥97% (HPLC)

Synonym(s):

D-Ala-D-(β-naphthyl)-Ala-Ala-Trp-D-Phe-Lys-NH2 TFA salt, D-Alanyl-3-(naphthalen-2-yl)-D-alanyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide, GHRP-2, Growth hormone-releasing peptide 2 trifluoroacetate

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About This Item

Empirical Formula (Hill Notation):
C45H55N9O6 · xC2HF3O2
CAS Number:
158861-67-7
Molecular Weight:
817.97 (free base basis)
MDL number:
MFCD00674876
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥97% (HPLC)

form

lyophilized powder

color

white to beige

storage temp.

−20°C

SMILES string

N[C@H](C)C(N[C@H](CC1=CC(C=CC=C2)=C2C=C1)C(N[C@@H](C)C(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@H](CC5=CC=CC=C5)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O

InChI

1S/C45H55N9O6/c1-27(47)41(56)52-38(24-30-19-20-31-14-6-7-15-32(31)22-30)43(58)50-28(2)42(57)53-39(25-33-26-49-35-17-9-8-16-34(33)35)45(60)54-37(23-29-12-4-3-5-13-29)44(59)51-36(40(48)55)18-10-11-21-46/h3-9,12-17,19-20,22,26-28,36-39,49H,10-11,18,21,23-25,46-47H2,1-2H3,(H2,48,55)(H,50,58)(H,51,59)(H,52,56)(H,53,57)(H,54,60)/t27-,28+,36+,37-,38-,39+/m1/s1

InChI key

HRNLPPBUBKMZMT-RDRUQFPZSA-N

Biochem/physiol Actions

Ghrelin/growth hormone secretagogue receptor (GHSR) agonist; Growth hormone-releasing peptide
Pralmorelin, also known as Growth hormone-releasing peptide 2 or GHRP-2, is an orally-active, synthetic peptide analogue of met-enkephalin that acts as a ghrelin/growth hormone secretagogue receptor (GHSR) agonist to selectively stimulate the ghrelin receptor and cause growth hormone release. Pralmorelin (GHRP-2) has been used clinically for the assessment of growth hormone deficiency (GHD), It has also been shown to have anti-inflammatory activity.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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P Ferro et al.
Drug testing and analysis, 9(1), 87-95 (2016-01-27)
Growth hormone releasing peptides (GHRPs) could be widely used by cheating athletes because they produce growth hormone (GH) secretion, so may generate an ergogenic effect in the body. Knowledge of the essential amino acids needed in GHRP structure for interaction
Hiroshi Arimura et al.
Endocrine journal, 63(6), 533-544 (2016-03-30)
The aim of this study was to evaluate the ability of the growth hormone-releasing peptide-2 (GHRP-2) test to clinically diagnose hypothalamo-pituitary-adrenal (HPA) axis failure. We performed an insulin tolerance test (ITT), CRH stimulation test, and GHRP-2 test on 47 patients
Yi-Ning Chao et al.
International journal of molecular sciences, 17(8) (2016-08-23)
Cyclooxygenase-2 (COX-2) and interleukin-8 (IL-8) are two important inflammatory mediators in ovulation. Ghrelin may modulate inflammatory signaling via growth hormone secretagogue receptors. We investigated the role of ghrelin in KGN human ovarian granulosa cells using protein kinase C (PKC) activator

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