Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

SML2055

Sigma-Aldrich

ZD0947

≥98% (HPLC)

Synonym(s):

3-[(4 S)5-Oxo-2-(trifluoromethyl)-1,4,5,6,7,8-hexahydroquinolin-4-yl] benzonitrile, 3-[(4S)-1,4,5,6,7,8-Hexahydro-5-oxo-2-(trifluoromethyl)-4-quinolinyl]-benzonitrile

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
$109.25
25 MG
$371.00

$109.25

List Price$115.00Save 5%
Web-Only Promotion

Available to ship onMay 05, 2025Details

Request a Bulk Order
Notify Me

Get notified when this item is ready to ship via email.

All Photos(1)

Select a Size

Change View
5 MG
$109.25
25 MG
$371.00

About This Item

Empirical Formula (Hill Notation):
C17H13F3N2O
CAS Number:
172649-40-0
Molecular Weight:
318.29
MDL number:
MFCD00944017
UNSPSC Code:
12352200
NACRES:
NA.77

$109.25

List Price$115.00Save 5%
Web-Only Promotion

Available to ship onMay 05, 2025Details

Request a Bulk Order
Notify Me

Get notified when this item is ready to ship via email.

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -625 to -575°, c = 0.5 in methanol

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C1C2=C(NC(C(F)(F)F)=C[C@H]2C3=CC(C#N)=CC=C3)CCC1

InChI

1S/C17H13F3N2O/c18-17(19,20)15-8-12(11-4-1-3-10(7-11)9-21)16-13(22-15)5-2-6-14(16)23/h1,3-4,7-8,12,22H,2,5-6H2/t12-/m0/s1

InChI key

RUVMMEREJMHLOS-LBPRGKRZSA-N

Related Categories

Biochem/physiol Actions

ZD0947 is potent ATP-sensitive K+ channels (KATP channels) opener. ZD0947 is an effective activator of smooth muscle-type KATP channels (SUR2B/Kir6.1 and SUR2B/Kir6.2) but is a partial antagonist of pancreatic-type KATP channels (i.e. SUR1/Kir6.2) and cardiac-type KATP channels (i.e. SUR2A/Kir6.2). ZD0947 potently inhibits carbacho-induced contraction in the strips of human detrusor.
potent ATP-sensitive K+ channels (KATP channels) opener

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000029410
0000029411
0000024071

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Aly M Abdel-Karim et al.
The Journal of urology, 168(2), 837-842 (2002-07-20)
The use of K+ channel openers is emerging as an attractive possibility for treating bladder overactivity. We tested the efficacy of the 2 adenosine triphosphate dependent K channel openers ZD6169 and ZD0947 on detrusor hyperreflexia after spinal cord injury in
Keisuke Mori et al.
European journal of pharmacology, 791, 773-779 (2016-10-30)
The effects of ZD0947, a novel ATP-sensitive K
M Aishima et al.
British journal of pharmacology, 149(5), 542-550 (2006-10-04)
ATP-sensitive K+ channels (K(ATP) channels) play important roles in regulating the resting membrane potential of detrusor smooth muscle. Actions of ZD0947, a novel KATP channel opener, on both carbachol (CCh)-induced detrusor contractions and membrane currents in human urinary bladder myocytes

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service