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SML1903

Sigma-Aldrich

IMB5046

≥98% (HPLC)

Synonym(s):

2-(4-Morpholinyl)-5-nitro-benzoic acid [4-(methylthio)phenyl]methyl ester

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5 MG
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5 MG
$61.46

About This Item

Empirical Formula (Hill Notation):
C19H20N2O5S
CAS Number:
1001571-08-9
Molecular Weight:
388.44
UNSPSC Code:
12352202
NACRES:
NA.77

$61.46

List Price$64.70Save 5%
Web-Only Promotion

Available to ship onMay 01, 2025Details

Request a Bulk Order

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C1=C(N2CCOCC2)C=CC([N+]([O-])=O)=C1)OCC3=CC=C(SC)C=C3

InChI

1S/C19H20N2O5S/c1-27-16-5-2-14(3-6-16)13-26-19(22)17-12-15(21(23)24)4-7-18(17)20-8-10-25-11-9-20/h2-7,12H,8-11,13H2,1H3

InChI key

VPXGOSNPXCNGAI-UHFFFAOYSA-N

Biochem/physiol Actions

IMB5046 is a microtubule inhibitor that has antitumor activity, overcoming multidrug-resistance.
IMB5046 is a microtubule inhibitor that has antitumor activity, overcoming multidrug-resistance. IMB5046 was cytotoxic with an IC50 range of 37 to 426 nM against multiple tumor cell lines, including some that were resistant to colchicine, vincristine and paclitaxel. IMB5046 was also active against human lung tumor xenografts. IMB5046 was found to bind to tubulin at the colchicine site, but with a different binding mode. IMB5046 inhibited tubulin polymerization, and induced G2/M arrest.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
027M4611V

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Yan-Bo Zheng et al.
Scientific reports, 6, 31472-31472 (2016-08-12)
Multidrug resistance is a major limitation for microtubule-binding agents in cancer treatment. Here we report a novel microtubule inhibitor (2-morpholin-4-yl-5-nitro-benzoic acid 4-methylsulfanyl-benzyl ester, IMB5046), its cytotoxicity against multidrug-resistant cell lines and its antitumor efficacy in animal models. IMB5046 disrupted microtubule

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