Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

SML1857

Sigma-Aldrich

LRE1

≥98% (HPLC)

Synonym(s):

6-Chloro-N4-cyclopropyl-N4-(2-thienylmethyl)-2,4-pyrimidinediamine, RU-0204277

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
$108.00
25 MG
$436.00

$108.00

Check Cart for Availability
Request a Bulk Order
Notify Me

Get notified when this item is ready to ship via email.

All Photos(1)

Select a Size

Change View
5 MG
$108.00
25 MG
$436.00

About This Item

Empirical Formula (Hill Notation):
C12H13ClN4S
CAS Number:
1252362-53-0
Molecular Weight:
280.78
MDL number:
MFCD23148480
UNSPSC Code:
12352200
NACRES:
NA.77

$108.00

Check Cart for Availability
Request a Bulk Order
Notify Me

Get notified when this item is ready to ship via email.

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

ClC1=CC(N(C2CC2)CC3=CC=CS3)=NC(N)=N1

InChI key

PDWZXKSZLRVSEH-UHFFFAOYSA-N

Biochem/physiol Actions

LRE1 is a selective allosteric inhibitor of soluble adenylyl cyclase (sAC), a ubiquitously expressed, essential component of cAMP-signaling. In contrast to G-protein-regulated transmembrane adenylyl cyclase, soluble adenylyl cyclase is directly activated by calcium and carbonate, and is dispersed throughout the cell cytoplasm. LRE1 was found to bind to the bicarbonate activator binding site. It inhibited cAMP accumulation in 4-4 cells with an IC50 of 11 μM, similar to that of KH7 and without its cellular toxicity.
Selective allosteric inhibitor of soluble adenylyl cyclase (sAC)

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000235015
017M4609V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Lavoisier Ramos-Espiritu et al.
Nature chemical biology, 12(10), 838-844 (2016-08-23)
The prototypical second messenger cAMP regulates a wide variety of physiological processes. It can simultaneously mediate diverse functions by acting locally in independently regulated microdomains. In mammalian cells, two types of adenylyl cyclase generate cAMP: G-protein-regulated transmembrane adenylyl cyclases and

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service