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SML1818

Sigma-Aldrich

Pirodavir

≥98% (HPLC)

Synonym(s):

4-[2-[1-(6-Methyl-3-pyridazinyl)-4-piperidinyl]ethoxy]-benzoic acid ethyl ester, Ethyl 4-[2-[1-(6-methyl-3-pyridazinyl)-4-piperidinyl]ethoxy]benzoate, R 77975, R-77975, R77,975

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About This Item

Empirical Formula (Hill Notation):
C21H27N3O3
CAS Number:
124436-59-5
Molecular Weight:
369.46
MDL number:
MFCD00866965
UNSPSC Code:
51111800
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(OCC)C1=CC=C(OCCC2CCN(C3=NN=C(C)C=C3)CC2)C=C1

InChI

1S/C21H27N3O3/c1-3-26-21(25)18-5-7-19(8-6-18)27-15-12-17-10-13-24(14-11-17)20-9-4-16(2)22-23-20/h4-9,17H,3,10-15H2,1-2H3

InChI key

KCHIOGFOPPOUJC-UHFFFAOYSA-N

Biochem/physiol Actions

Pirodavir is a broad-spectrum antipicornavirus agent that targets viral capsid protein VP1. Pirodavir is a broad spectrum inhibitor of human rhinovirus (HRV).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Céline Lacroix et al.
Virology journal, 12, 106-106 (2015-07-15)
Rhinovirus infections do not only cause common colds, but may also trigger severe exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Even though rhinoviruses have been the focus of extensive drug development efforts in the past, an anti-rhinoviral drug
Chris Mello et al.
Antimicrobial agents and chemotherapy, 58(3), 1546-1555 (2013-12-25)
Human rhinovirus type C (HRV-C) is a newly discovered enterovirus species frequently associated with exacerbation of asthma and other acute respiratory conditions. Until recently, HRV-C could not be propagated in vitro, hampering in-depth characterization of the virus replication cycle and
Donald F Smee et al.
Antiviral research, 131, 61-65 (2016-04-12)
Compounds were evaluated for antiviral activity in rhabdomyosarcoma (RD) cells against a recent 2014 clinical isolate of enterovirus D68 (EV-D68), a 1962 strain of EV-68D, rhinovirus 87 (RV-87, serologically the same as EV-D68), and enterovirus 71 (EV-71). Test substances included

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