Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

SML1764

Sigma-Aldrich

AZD9272

≥98% (HPLC)

Synonym(s):

3-(5-Fluoropyrid-2-yl)-5-(3-cyano-5-fluorophenyl)-1,2,4-oxadiazole, 3-Fluoro-5-(3-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol5-yl)benzonitrile, 3-Fluoro-5-[3-(5-fluoro-2-pyridinyl)-1,2,4-oxadiazol-5-yl]-benzonitrile

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C14H6F2N4O
CAS Number:
327056-26-8
Molecular Weight:
284.22
MDL number:
MFCD26394953
UNSPSC Code:
12352202
PubChem Substance ID:
329826057
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

room temp

SMILES string

FC1=CC(C#N)=CC(C2=NC(C3=CC=C(F)C=N3)=NO2)=C1

Biochem/physiol Actions

AZD9272 is a long acting, CNS penetrant, potent and selective mGluR5 antagonist.
AZD9272 is a potent and selective mGluR5 antagonist.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
106M4757V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Patrick Raboisson et al.
Bioorganic & medicinal chemistry letters, 22(22), 6974-6979 (2012-10-11)
AZD9272 and AZD6538 are two novel mGluR5 negative allosteric modulators selected for further clinical development. An initial high-throughput screening revealed leads with promising profiles, which were further optimized by minor, yet indispensable, structural modifications to bring forth these drug candidates.
J Kalliomäki et al.
European journal of pain (London, England), 17(10), 1465-1471 (2013-05-08)
This study aimed to investigate the effect of a single dose of the mGluR5-antagonist AZD9272 on electrically induced pain, central sensitization and axon reflex flare. This was a randomized, double-blind, placebo-controlled crossover study. Twenty-five healthy male volunteers received a single
Michael D B Swedberg et al.
The Journal of pharmacology and experimental therapeutics, 350(2), 212-222 (2014-05-31)
The metabotropic glutamate receptor 5 (mGluR5) antagonists fenobam, MPEP (2-methyl-6-(phenylethynyl)pyridine), and MTEP (3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine) were previously shown to not cause N-methyl-D-aspartate antagonist-like psychoactive effects in phencyclidine (PCP) drug discrimination studies, but to cause MTEP-like discrimination in rats, suggesting that the psychoactive

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service