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Key Documents

SML1704

Sigma-Aldrich

Quininib

≥98% (HPLC)

Synonym(s):

(E)-2-[2-(2-Quinolinyl)ethenyl]-phenol, 2-[(E)-2-(Quinolin-2-yl)vinyl]phenol

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About This Item

Empirical Formula (Hill Notation):
C17H13NO
CAS Number:
Molecular Weight:
247.29
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1=CC=CC=C1/C=C/C2=NC3=C(C=CC=C3)C=C2

InChI

1S/C17H13NO/c19-17-8-4-2-6-14(17)10-12-15-11-9-13-5-1-3-7-16(13)18-15/h1-12,19H/b12-10+

InChI key

NXNDEWNGCMCWMA-ZRDIBKRKSA-N

Biochem/physiol Actions

Quininib is a cell penetrant, potent and selective cysteinyl leukotriene receptor 1 and 2 (CysLT1-2) antagonist that potently inhibits angiogenesis in a range of cell and tissue systems. Quininib inhibits retinal revascularisation in OIR mice. Quininib is effective at inhibiting angiogenesis in the mouse oxygen-induced retinopathy model. Additionally quininib inhibits endothelin-converting enzyme-2 (ECE-2).
Quininib is a cell penetrant, potent and selective cysteinyl leukotriene receptor 1 and 2 (CysLT1-2) antagonist.

pictograms

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Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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