SML1677

Tarocin A1

≥98% (HPLC)

• Synonym(s): (4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-(3-(isoquinolin-4-yl)propanoyl)-4-methyloxazolidin-2-one
• Empirical Formula (Hill Notation): C₂₄H₁₈F₆N₂O₃
• CAS Number: 2095106-05-9
• Molecular Weight: 496.40
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826010
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: C[C@H](N1C(CCC2=C(C=CC=C3)C3=CN=C2)=O)[C@@H](C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)OC1=O
• InChI: 1S/C24H18F6N2O3/c1-13-21(16-8-17(23(25,26)27)10-18(9-16)24(28,29)30)35-22(34)32(13)20(33)7-6-15-12-31-11-14-4-2-3-5-19(14)15/h2-5,8-13,21H,6-7H2,1H3/t13-,21-/m0/s1
• InChI key: XWMRKUPNQVITEC-ZSEKCTLFSA-N

Description

Biochem/physiol Actions

Tarocin A1 is an oxazolidinone which inhibits TarO, the first enzyme in teichoic acid synthesis.

Tarocin A1 is an oxazolidinone which inhibits TarO, the first enzyme in teichoic acid synthesis. Tarocin A1 has an IC₅₀ value of 40 nM in a biochemical TarO assay. Tarocin A does not inhibit bacterial growth alone, and exhibits no cytotoxicity against HeLa cells, but it has potent bactericidal syergism with broad spectrum β-lactams, and may restore the clinical efficacy of existing β-lactam antibiotics.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable