SML1676

R9-caPep trifluoroacetate salt

≥95% (HPLC)

• Synonym(s): D-Arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-L-cysteinyl-L-cysteinyl-L-leucylglycyl-L-isoleucyl-L-prolyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-tyrosine, H-RDRDRDRDRDRDRDRDRD-CC-LGIPEQEY-OH
• Empirical Formula (Hill Notation): C₁₀₃H₁₈₃N₄₇O₂₆S₂ · xC₂HF₃O₂
• Molecular Weight: 2559.98 (free base basis)
• UNSPSC Code: 12352202

Properties

• assay: ≥95% (HPLC)
• form: powder
• color: white to off-white
• shipped in: wet ice
• storage temp.: −20°C

Description

Biochem/physiol Actions

R9-caPep is an octadecapeptide composed of N-terminal membrane-permeant nona-D-arginine sequence linked via a -Cys-Cys- spacer to a C-terminal proliferating cell nuclear antigen (PCNA) interdomain loop-derived sequence (L126-Y133) that mediates PCNA interaction with its binding partners via their PIP-box domains.

R9-caPep is an octadecapeptide composed of N-terminal membrane-permeant nona-D-arginine sequence linked via a -Cys-Cys- spacer to a C-terminal proliferating cell nuclear antigen (PCNA) interdomain loop-derived sequence (L126-Y133) that mediates PCNA interaction with its binding partners via their PIP-box domains. R9-caPep selectively kills human neuroblastoma cells (IC₅₀ = 10 - 32 μM vs. IC₅₀ = 98 μM/PBMCs and >100 μM/neural crest stem cells), especially those with MYCN gene amplification, by interfering with PCNA-dependent replication fork extension and DSB HR repair, resulting in exacerbated replication stress. R9-caPep intratumoral injection (3 times a week) is reported to suppress SK-N-BE(2)c xenograft tumor expansion in mice in vivo.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable