SML1675
SKY Peptide trifluoroacetate salt
≥98% (HPLC)
Synonym(s):
L-Arginyl-L-arginyl-L-tyrosylglycyl-L-threonyl-L-seryl-L-lysyl-L-tyrosyl-L-glutamine TFA salt, RRYGTSKYQ
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About This Item
Empirical Formula (Hill Notation):
C50H79N17O15 · xC2HF3O2
CAS Number:
Molecular Weight:
1158.27 (free base basis)
UNSPSC Code:
12352202
NACRES:
NA.77
assay
≥98% (HPLC)
form
powder
color
white to off-white
shipped in
wet ice
storage temp.
−20°C
Biochem/physiol Actions
SKY Peptide is a non-cytotoxic and stable nonapeptide modeled after human neutrophil peptide 1 (HNP1, a-defensin) β strand 2 CCL5-binding mode to optimally complete against HNP1 for CCL5 interaction (EC50 ~ 0.1 μg/mL against 10 μg/mL HNP1 and 1 μg/mL CCL5 heteromer formation on HUVECs) without affecting CCL5 and cell surface CCR5 interaction. SKY Peptide is shown to inhibit HNP1-CCL5 heteromer-dependent classical monocytes adhesion both in cultures in vitro (EC50 <1 μg/mL; 10 μg/mL HNP1 and 1 μg/mL CCL5 over HUVEC monolayer) and in mice in vivo.
SKY Peptide is a non-cytotoxic and stable nonapeptide.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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