SML1673
MM-206
≥98% (HPLC)
Synonym(s):
2,3,4,5,6-Pentafluoro-N-(4-hydroxy-3-(phenylthio)naphthalen-1-yl)benzenesulfonamide, MM 206
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About This Item
Empirical Formula (Hill Notation):
C22H12F5NO3S2
CAS Number:
Molecular Weight:
497.46
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
assay
≥98% (HPLC)
form
powder
storage temp.
2-8°C
SMILES string
OC(C1=C2C=CC=C1)=C(SC3=CC=CC=C3)C=C2NS(C4=C(F)C(F)=C(F)C(F)=C4F)(=O)=O
Biochem/physiol Actions
MM-206 is a cell-permeable, non-cytotoxic naphthalene sulfonamide compound effectively inhibits STAT3 DNA-binding activity (IC50 = 2.45 μM). MM-206 inhibits G-CSF-stimulated STAT3 phosphorylation in human AML cells (IC50 = 0.8-1.9 μM) and exhibits higher apoptosis-inducing potency in AML (EC50 in μM = 6.3/p198, 7.1/MV4-11 and 7.6/HL-60) than ALL cultures (EC50 in μM = 26.0/KOPN-8 & 42.2/RS4-11). When administered via daily i.p. dosing (30 mg/kg), MM-206 is efficacious in prolonging the survival of mice received MV4-11 AML xenograft.
MM-206 is a cell-permeable, non-cytotoxic naphthalene sulfonamide compound effectively inhibits STAT3 DNA-binding activity.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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