SML1660

NA-17

≥98% (HPLC)

• Synonym(s): 2-[2-(1,3-Benzodioxol-5-yl)ethyl]-6-[[3-(dimethylamino)propyl]amino]-1H-benz[de]isoquinoline-1,3(2H)-dione, 6-(1,3-Propanediamine-N,N-dimethyl-N’-)-N’’-(3,4-methylenedioxy-phenethylamin)-1,8-naphthalimide
• Empirical Formula (Hill Notation): C₂₆H₂₇N₃O₄
• CAS Number: 1708948-28-0
• Molecular Weight: 445.51
• UNSPSC Code: 12352202
• PubChem Substance ID: 329825999
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: light yellow to orange
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: CN(C)CCCNC1=CC=C(C(N(CCC2=CC=C(OCO3)C3=C2)C4=O)=O)C5=C4C=CC=C51
• InChI: 1S/C26H27N3O4/c1-28(2)13-4-12-27-21-9-8-20-24-18(21)5-3-6-19(24)25(30)29(26(20)31)14-11-17-7-10-22-23(15-17)33-16-32-22/h3,5-10,15,27H,4,11-14,16H2,1-2H3
• InChI key: ACOYDEZACFFCPN-UHFFFAOYSA-N

Description

Biochem/physiol Actions

NA-17 is a fluorescent naphthalimide that induces accumulation of activated p53 in mitochondria and nuclei of NSCLC cells.

NA-17 is a fluorescent naphthalimide that induces accumulation of activated p53 in mitochondria and nuclei of NSCLC cells. NA-17 reorganizes the Bak–Bcl-xl complex, promotes p53 phosphorylation without altering the expression of p53, induces cell cycle arrest at the G1 phase and apoptosis. NA-17 exhibits potent anticancer activities in multiple cancer cell lines showing low toxicity to normal cell lines.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P301 + P312 + P330 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable