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Key Documents

SML1597

Sigma-Aldrich

SRI-29574

≥98% (HPLC)

Synonym(s):

N-(2,2-Diphenylethyl)-2-(imidazo[1,2-a]pyridin-6-yl)quinazolin-4-amine

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About This Item

Empirical Formula (Hill Notation):
C29H23N5
Molecular Weight:
441.53
UNSPSC Code:
12352202
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to light brown

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

DAT is crucial for regulating the levels of DA (dopamine). It is also responsible for the reuptake of 1-methyl-4-phenylpyridinium (MPP+), neurotoxin which mediates symptoms similar to Parkinson′s disease.[1] Changes in DAT activity is associated with attention-deficit/hyperactivity and autism spectrum disorders.[2]
SRI-29574 is a potent DAT (dopamine transporter) allosteric modulator that partially inhibits DAT uptake without affecting binding to DAT.
SRI-29574 is a potent DAT (dopamine transporter) allosteric modulator that partially inhibits DAT uptake without affecting binding to DAT. SRI-29574 is a noncompetitive inhibitor of [3H]DA uptake. Also SRI-29574 partially inhibits SERT and NET uptake.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
046M4617V

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Sijia Wu et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(50), 15480-15485 (2015-12-02)
The dopamine (DA) transporter (DAT) facilitates high-affinity presynaptic DA reuptake that temporally and spatially constrains DA neurotransmission. Aberrant DAT function is implicated in attention-deficit/hyperactivity disorder and autism spectrum disorder. DAT is a major psychostimulant target, and psychostimulant reward strictly requires
Beryl Luk et al.
PloS one, 10(8), e0136641-e0136641 (2015-08-26)
The regulation of the dopamine transporter (DAT) impacts extracellular dopamine levels after release from dopaminergic neurons. Furthermore, a variety of protein partners have been identified that can interact with and modulate DAT function. In this study we show that DJ-1

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