SML1562
HIV inhibitor 18A
≥98% (HPLC)
Synonym(s):
18A, N-2,1,3-Benzothiadiazol-4-yl-2-[(4-hydroxyphenyl)methylene]-hydrazinecarboxamide
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About This Item
Empirical Formula (Hill Notation):
C14H11N5O2S
CAS Number:
Molecular Weight:
313.33
UNSPSC Code:
12352202
NACRES:
NA.77
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
HIV inhibitor 18A is a broad spectrum viral fusion and viral entry inhibitor. HIV entry requires several steps in sequence starting with HIV surface glycoprotein gp120 binding to the CD4 receptor followed by a conformational change in gp120, exposing a second recognition site that binds the co-receptor C-C chemokine receptor (CCR5) on the host cell, eventually resulting in the fusion of HIV and the T cell membranes, allowing entry of the viral core into the cell. HIV inhibitor 18A prevents the surface envelope glycoprotein from fusing with host cells by blocking envelope glycoprotein transitions critical for entry rather than interfering with CD4 or CCR5 binding.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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