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Key Documents

SML1511

Sigma-Aldrich

CS1

≥98% (HPLC)

Synonym(s):

4-(6-Hydroxy-2-naphthalenyl)-1,2-benzenediol

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About This Item

Empirical Formula (Hill Notation):
C16H12O3
CAS Number:
Molecular Weight:
252.26
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to light brown

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

OC1=CC=C2C(C=CC(C3=CC(O)=C(O)C=C3)=C2)=C1

InChI

1S/C16H12O3/c17-14-5-3-11-7-10(1-2-12(11)8-14)13-4-6-15(18)16(19)9-13/h1-9,17-19H

InChI key

LDFFDYWHCCDSBO-UHFFFAOYSA-N

Biochem/physiol Actions

CS1 is a selective and potent inhibitor of topoisomerase IIα (TopoIIα) that displays less toxicity than etoposide.
CS1 is a selective and potent inhibitor of topoisomerase IIα (TopoIIα) that potently inhibits a proliferation of cancer cell lines including MDA-MB-231 and A548 cells, with less toxicity than etoposide. CS1 is a nonintercalating topoisomerase IIα (Topo IIα) inhibitor, which stabilizes the DNA-Topo IIα cleavage complex.

pictograms

Exclamation markEnvironment

signalword

Warning

Hazard Classifications

Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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