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Key Documents

SML1499

Sigma-Aldrich

LW479

≥98% (HPLC)

Synonym(s):

6-[2-[2-(3-Bromophenyl)-4-oxo-3-thiazolidinyl]phenoxy]-N-hydroxy-hexanamide

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About This Item

Empirical Formula (Hill Notation):
C21H23BrN2O4S
CAS Number:
Molecular Weight:
479.39
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

BrC1=CC(C2N(C3=CC=CC=C3OCCCCCC(NO)=O)C(CS2)=O)=CC=C1

InChI

1S/C21H23BrN2O4S/c22-16-8-6-7-15(13-16)21-24(20(26)14-29-21)17-9-3-4-10-18(17)28-12-5-1-2-11-19(25)23-27/h3-4,6-10,13,21,27H,1-2,5,11-12,14H2,(H,23,25)

InChI key

XRAVVAITOQNASO-UHFFFAOYSA-N

Biochem/physiol Actions

LW479 is a potent histone deacetylase inhibitor (HDACI) that down-regulates EGFR expression.
LW479 is a potent histone deacetylase inhibitor (HDACI) that down-regulates EGFR expression. Apparently, LW479 blocks the binding of the transcription factor Sp1 and HDAC1 to the EGFR promoter region. LW479 potently induces cell cycle arrest and apoptosis breast cancer cell lines. Also LW479 suppressed breast tumor growth and pulmonary metastasis in nude mice.

pictograms

Exclamation markEnvironment

signalword

Warning

Hazard Classifications

Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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