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Key Documents

SML1477

Sigma-Aldrich

MPI-0479605 hydrochloride

≥98% (HPLC)

Synonym(s):

N6-Cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]-9H-purine-2,6-diamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C22H29N7O · HCl
CAS Number:
Molecular Weight:
443.97
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

CC(C=C(N1CCOCC1)C=C2)=C2NC3=NC4=C(N=CN4)C(NC5CCCCC5)=N3.[H]Cl

InChI

1S/C22H29N7O.ClH/c1-15-13-17(29-9-11-30-12-10-29)7-8-18(15)26-22-27-20-19(23-14-24-20)21(28-22)25-16-5-3-2-4-6-16;/h7-8,13-14,16H,2-6,9-12H2,1H3,(H3,23,24,25,26,27,28);1H

InChI key

BYBIFMLUJUNGNX-UHFFFAOYSA-N

Biochem/physiol Actions

MPI-0479605 is a potent ATP-competitive inhibitor of the dual-specificity kinase Mps-1, which is essential for maintainence of spindle assembly checkpoint and chromalomal spindle attachment. Treatment of cells with MPI-0479605 causes aberrant mitosis and aneuploidy and inhibits growth of tumor xenografts in vivo. MPI-0479605 has an IC50 value of 1.8 nM.
MPI-0479605 is a potent ATP-competitive inhibitor of the dual-specificity kinase Mps-1.

pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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