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Key Documents

SML1470

Sigma-Aldrich

PACA

≥98% (HPLC)

Synonym(s):

3-(3,4-Dihydroxyphenyl)-N-2-propyn-1-yl-2-propenamide

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About This Item

Empirical Formula (Hill Notation):
C12H11NO3
CAS Number:
Molecular Weight:
217.22
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to light brown

solubility

DMSO: 25 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1=CC=C(/C=C/C(NCC#C)=O)C=C1O

InChI

1S/C12H11NO3/c1-2-7-13-12(16)6-4-9-3-5-10(14)11(15)8-9/h1,3-6,8,14-15H,7H2,(H,13,16)/b6-4+

InChI key

HLHSUNWAPXINQU-GQCTYLIASA-N

Biochem/physiol Actions

Nerve growth factor potentiator, activator of Nrf2/HO-1
PACA is a potentiator of NGF-induced neurite outgrowth that attenuates 6-hydroxydopamine (6-OHDA) neurotoxicity in dopaminergic PC12 cells. PACA induced the nuclear translocation of transcription factor Nrf2 and the expression of antioxidant heme oxygenase-1 (HO-1).

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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