Bithionol was originally used as an anthelmintic. Bithionol has more recently been investigated for potential use as an anti-ovarian cancer drug and as a possible treatment for Alzheimer′s disease. Bithionol inhibited Aβ42 seeding capacity and fibril growth, stabilized diffuse amyloid plaques, reduced the levels of Aβ42 oligomers and ameliorated synapse loss, neuronal damage and astrogliosis in a transgenic mouse model of Alzheimer′s disease. Bithionol appears to act through several mechanisms of action including uncoupling of oxidative phosphorylation, ROS generation, NF-κB inhibition, autotaxin inhibition, and as an activator of Slack sodium-activated potassium (KNa) channels.
Aβ accumulation plays a central role in the pathogenesis of Alzheimer's disease (AD). Recent studies suggest that the process of Aβ nucleated polymerization is essential for Aβ fibril formation, pathology spreading and toxicity. Therefore, targeting this process represents an effective
Drug resistance is a cause of ovarian cancer recurrence and low overall survival rates. There is a need for more effective treatment approaches because the development of new drug is expensive and time consuming. Alternatively, the concept of 'drug repurposing'
A reliable and highly sensitive screening method based on liquid chromatography coupled withtriple-quadrupoleelectrospray tandemmass spectrometry (LC-MS/MS) analysis has been developed for the detection and quantification of three veterinary drugs, including buparvaquone, nystatin, and etomidate impurity B CRS. The tested drugs
Journal of neurochemistry, 157(6), 1861-1875 (2020-10-08)
The endothelial cells of the blood-brain barrier participate in the regulation of glutamate concentrations in the brain interstitial fluid by taking up brain glutamate. However, endothelial glutamate metabolism has not been characterized, nor is its role in brain glutamate homeostasis
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