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SML1377

Sigma-Aldrich

R-7050

≥95% (HPLC)

Synonym(s):

8-Chloro-4-(phenylsulfanyl)-1-(trifluoromethyl)[1,2,4]triazolo[4,3-a]quinoxaline, 8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline

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5 MG
$100.00
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$309.00

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5 MG
$100.00
25 MG
$309.00

About This Item

Empirical Formula (Hill Notation):
C16H8ClF3N4S
CAS Number:
303997-35-5
Molecular Weight:
380.77
MDL number:
MFCD00140737
UNSPSC Code:
51111800
PubChem Substance ID:
329825827
NACRES:
NA.77

$100.00

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Quality Level

100

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

shipped in

wet ice

storage temp.

−20°C

SMILES string

ClC1=CC=C(N=C(SC2=CC=CC=C2)C3=NN=C(C(F)(F)F)N34)C4=C1

InChI

1S/C16H8ClF3N4S/c17-9-6-7-11-12(8-9)24-13(22-23-15(24)16(18,19)20)14(21-11)25-10-4-2-1-3-5-10/h1-8H

InChI key

SUUMKHOVGVYGOP-UHFFFAOYSA-N

Biochem/physiol Actions

R-7050 is a cell-permeable TNF-α receptor antagonist that blocks TNF-α-induced binding of TNF-αRI with TNFαR-associated death domain protein and receptor interacting protein 1, blocking internalization of the TNFα-TNFαR complex. R-7050 was found to reduce neurovascular injury in a mouse model of hemorrhagic stroke.
R-7050 is a cell-permeable TNF-α receptor antagonist.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
085M4737V

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Thomas Mudersbach et al.
PloS one, 14(5), e0216218-e0216218 (2019-05-03)
The angiotensin-converting enzyme (ACE) plays a central role in the renin-angiotensin system, which is involved in the regulation of blood pressure. Alterations in ACE expression or activity are associated with various pathological phenotypes, particularly cardiovascular diseases. In human endothelial cells

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