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SML1370

Sigma-Aldrich

A-779 trifluoroacetate salt

≥98% (HPLC)

Synonym(s):

A779 trifluoroacetate salt, Asp1-Arg2-Val3-Tyr4-Ile5-His6-D-Ala7, D-Ala7-Ang-(1-7), DRVYIHA (Modification: Ala-7 = D-Ala), DRVYIHa trifluoroacetate salt, H-Asp-Arg-Val-Tyr-Ile-His-D-Ala-OH trifluoroacetate salt, [7-D-ALA]-angiotensin-(1-7) trifluoroacetate salt

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About This Item

Empirical Formula (Hill Notation):
C39H60N12O11 · xC2HF3O2
CAS Number:
159432-28-7
Molecular Weight:
872.97 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

lyophilized powder

color

white to off-white

shipped in

wet ice

storage temp.

−20°C

Biochem/physiol Actions

A-779 (D-Ala7-Ang-(1-7)) is a potent and selective antagonist of angiotensin (1-7), an endogenous peptide that acts through activation of a non-AT1, non-AT2 receptor, Mas, and opposes the activity of angiotensin. A-779 has an IC50 of 0.3 nM for Mas with negligible affinity for either AT1R or AT2R.
This blocking angiotensin action affects cardiovascular function.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cardiovascular actions of angiotensin-(1-7)
Ferreira AJ and Santos RAS
Brazilian journal of medical and biological research, 38(4), 499-507 (2005)
Gustavo B Lamy et al.
Frontiers in physiology, 12, 682711-682711 (2021-07-30)
Central micturition control and urine storage involve a multisynaptic neuronal circuit for the efferent control of the urinary bladder. Electrical stimulation of the lateral preoptic area (LPA) at the level of the decussation of the anterior commissure in cats evokes

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