SML1338

L-779450

≥98% (HPLC)

• Synonym(s): 2-Chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-imidazol-5-yl]-phenol, L 779450
• Empirical Formula (Hill Notation): C₂₀H₁₄ClN₃O
• CAS Number: 303727-31-3
• Molecular Weight: 347.80
• MDL number: MFCD12828750
• UNSPSC Code: 12352202
• PubChem Substance ID: 329825796
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: ClC(C(O)=C1)=CC=C1C(N=C(C2=CC=CC=C2)N3)=C3C4=CC=NC=C4
• InChI: 1S/C20H14ClN3O/c21-16-7-6-15(12-17(16)25)19-18(13-8-10-22-11-9-13)23-20(24-19)14-4-2-1-3-5-14/h1-12,25H,(H,23,24)
• InChI key: WXJLXRNWMLWVFB-UHFFFAOYSA-N

Description

Biochem/physiol Actions

L-779450 is a potent inhibitor in Raf-induced proliferation of Raf-1 and A-Raf-1 kinases.

L-779450 is a potent inhibitor in Raf-induced proliferation of Raf-1 and A-Raf-1 kinases. Raf inhibition is a target for anti-cancer therapy. Raf exists in three isoforms: Raf-1, A-Raf, and B-Raf, which are expressed at different levels in different cell types, tissues, and cancer states. L-779450 compound′s pharmacology found it to inhibit proliferation in Raf-1 and A-Raf, but not B-Raf responsive cells. L-779450 has been used as a reference Raf inhibitor to discover other compounds.

Safety Information

• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3