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Key Documents

SML1304

Sigma-Aldrich

KRCA-0008

≥98% (HPLC)

Synonym(s):

1,1′-[(5-Chloro-2,4-pyrimidinediyl)bis[imino(3-methoxy-4,1-phenylene)-4,1-piperazinediyl]]bis-ethanone, KRCA 0008, KRCA0008

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About This Item

Empirical Formula (Hill Notation):
C30H37ClN8O4
CAS Number:
Molecular Weight:
609.12
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to brown

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C30H37ClN8O4/c1-20(40)36-9-13-38(14-10-36)22-5-7-25(27(17-22)42-3)33-29-24(31)19-32-30(35-29)34-26-8-6-23(18-28(26)43-4)39-15-11-37(12-16-39)21(2)41/h5-8,17-19H,9-16H2,1-4H3,(H2,32,33,34,35)

InChI key

TXDIRJCYNAWBOS-UHFFFAOYSA-N

Biochem/physiol Actions

KRCA-0008 is a potent and selective ALK (aplastic lymphoma kinase) and Ack1 inhibitor that exhibits in vivo efficacy in xenograft mice model. KRCA-0008 potently inhibits ALK mutants L1196M, C1156Y, F1174L and R1275Q.
KRCA-0008 is a potent and selective ALK (aplastic lymphoma kinase) and Ack1 inhibitor.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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