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Key Documents

SML1204

Sigma-Aldrich

ML318

≥98% (HPLC)

Synonym(s):

2-(4-Fluorophenyl)-2-(6-(trifluoromethyl)pyridin-2-yl)acetonitrile

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About This Item

Empirical Formula (Hill Notation):
C14H8F4N2
CAS Number:
1610516-67-0
Molecular Weight:
280.22
UNSPSC Code:
12352202
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

ML318 is a biaryl nitrile inhibitor of PvdQ acylase.[1] It decreases the intracellular uptake of iron inside the bacteria.[2]
ML318 is an inhibitor of the siderophore PvdQ (pyoverdine Q), a peptide iron scavenger found in bacteria. ML318 inhibits the biosynthesis of one step in the pyoverdine biosynthesis with an IC50 of 20 nM, and is active in cells.
ML318 is an inhibitor of the siderophore PvdQ (pyoverdine Q).

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
015M4728V

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Identification of a small molecule inhibitor of Pseudomonas aeruginosa PvdQ acylase, an enzyme involved in siderophore pyoverdine synthesis
Probe Reports from the NIH Molecular Libraries Program (2013)
Jacqueline M Wurst et al.
ACS chemical biology, 9(7), 1536-1544 (2014-05-16)
Pseudomonas aeruginosa produces the peptide siderophore pyoverdine, which is used to acquire essential Fe(3+) ions from the environment. PvdQ, an Ntn hydrolase, is required for the biosynthesis of pyoverdine. PvdQ knockout strains are not infectious in model systems, suggesting that

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