SML1203

2-PMAP

≥98% (HPLC)

• Synonym(s): (2-Pyridylmethyl)(2-hydroxyphenyl)amine, 2-N-(2-Pyridylmethyl)aminophenol, 2-[(2-Pyridinylmethyl)amino]-phenol; (2-Hydroxyphenyl)(2-pyridylmethyl)amine
• Empirical Formula (Hill Notation): C₁₂H₁₂N₂O
• CAS Number: 102212-26-0
• Molecular Weight: 200.24
• MDL number: MFCD24550644
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825716
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: , white to dark brown
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: OC1=CC=CC=C1NCC2=NC=CC=C2
• InChI: 1S/C12H12N2O/c15-12-7-2-1-6-11(12)14-9-10-5-3-4-8-13-10/h1-8,14-15H,9H2
• InChI key: GXJRVWZNMZGWAQ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

2-PMAP is a brain penetrant inhibitor of amyloid precursor protein (APP) production.

2-PMAP is a brain penetrant inhibitor of amyloid precursor protein (APP) production. 2-PMAP lowers levels of the amyloid precursor protein (APP) in CHO APP751SW cells. Also it reduces brain level of APP in mice model. 2-PMAP exhibits no cellular toxicity up to 100 μM.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable