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Key Documents

SML1201

Sigma-Aldrich

LT175

≥98% (HPLC)

Synonym(s):

(αS)- α−([1,1′-Biphenyl]-4-yloxy)-benzenepropanoic acid

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About This Item

Empirical Formula (Hill Notation):
C21H18O3
CAS Number:
Molecular Weight:
318.37
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

LT175 is a dual PPARα/γ agonist that exhibit partial agonist profile at PPARγ.
LT175 is a dual PPARα/γ agonist that exhibit partial agonist profile at PPARγ. LT175 modulates lipid and glucose metabolism with reduced adipogenic activity. Also, LT175 significantly reduces plasma glucose, insulin, non-esterified fatty acids, triglycerides and cholesterol. LT175 decreases body weight, adipocyte size and white adipose tissue mass in mice on high fat diet. It appears that LT175 binds to different region of PPARγ than rosiglitazone (and other glitazones).

pictograms

Skull and crossbonesEnvironment

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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