SML1167

4BP-TQS

≥98% (HPLC)

• Synonym(s): 4-(4-Bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
• Empirical Formula (Hill Notation): C₁₈H₁₇BrN₂O₂S
• CAS Number: 360791-49-7
• Molecular Weight: 405.31
• MDL number: MFCD00981752
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825697
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: BrC1=CC=C(C2C(CC=C3)C3C(C=C(S(N)(=O)=O)C=C4)=C4N2)C=C1
• InChI: 1S/C18H17BrN2O2S/c19-12-6-4-11(5-7-12)18-15-3-1-2-14(15)16-10-13(24(20,22)23)8-9-17(16)21-18/h1-2,4-10,14-15,18,21H,3H2,(H2,20,22,23)
• InChI key: YNCXHXYZTLIZTO-UHFFFAOYSA-N

Description

Biochem/physiol Actions

4BP-TQS is an atypical agonist of a7-nAChR that binds to the receptor in an intrasubunit cavity, and activates the channel via a mechanism that is distinct from conventional agonists. Maximal activation of a7-nAChR by 4BP-TQS is eight fold greater than activation by a maximum dose of acetylcholine (Ach), and 4BP-TQS can poteniate an EC₁₀ concentration of ACh to invoke a response that is 540-fold higher than the maximal dose of ACh alone.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable