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Key Documents

SML1164

Sigma-Aldrich

SKLB1002

≥98% (HPLC)

Synonym(s):

2-((6,7-Dimethoxyquinazolin-4-yl)thio)-5-methyl-1,3,4-thiadiazole, 6,7-Dimethoxy-4-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]-quinazoline, SKLB 1002

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About This Item

Empirical Formula (Hill Notation):
C13H12N4O2S2
CAS Number:
Molecular Weight:
320.39
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

CC1=NN=C(S1)SC2=C(C=C(OC)C(OC)=C3)C3=NC=N2

InChI

1S/C13H12N4O2S2/c1-7-16-17-13(20-7)21-12-8-4-10(18-2)11(19-3)5-9(8)14-6-15-12/h4-6H,1-3H3

InChI key

RQVGFDBMONQTBC-UHFFFAOYSA-N

Biochem/physiol Actions

SKLB1002 is a cell permeable and potent VEGFR2 inhibitor that potently inhibits HUVEC cells proliferation, migration, invasion, and tube formation. It appears that SKLB1002 inhibits VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase, focal adhesion kinase, and Src. SKLB1002 inhibits angiogenesis.
SKLB1002 is a cell permeable and potent VEGFR2 inhibitor.

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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