SML1158

(2S)-Hypusine dihydrochloride

≥95% (HPLC)

• Synonym(s): (+)-Hypusine dihydrochloride, N6-[(2RS)-4-Amino-2-hydroxybutyl]-L-lysine dihydrochloride
• Empirical Formula (Hill Notation): C₁₀H₂₃N₃O₃ · 2HCl
• Molecular Weight: 306.23
• UNSPSC Code: 12352209
• PubChem Substance ID: 329825688
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 15 mg/mL, clear
• storage temp.: −20°C
• SMILES string: [H]Cl.[H]Cl.N[C@H](C(O)=O)CCCCNCC(O)CCN
• InChI: 1S/C10H23N3O3.2ClH/c11-5-4-8(14)7-13-6-2-1-3-9(12)10(15)16;;/h8-9,13-14H,1-7,11-12H2,(H,15,16);2*1H/t8?,9-;;/m0../s1
• InChI key: UTSZZUVUESAPQD-AHBBCRTASA-N

Description

Biochem/physiol Actions

(2S)-Hypusine is an unusual amino acid found only in eukaryotic translation initiation factor 5A (eIF5A) and a similar protein in archaebacteria. (2S)-Hypusine is formed by posttranslational modification of a lysine with the addition of the 4-aminobutyl moiety from the polyamine spermidine. There is increasing interest in the polyamine-hypusine axis and eIF5A, its a role in cell growth and differentiation, and a recent paper on the polyamine-hypusine axis as a potential new tumour suppressor network.

(2S)-Hypusine is an unusual amino acid found only in eukaryotic translation initiation factor 5A (eIF5A).

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable