SML1127

Terpendole E

≥95% (HPLC)

• Synonym(s): (2S,4R,4aR,4bR,6aS,12bS,12cS,14aS)- 3,4,4a,4b,5,6,6a,7,12,12b,12c,13,14,14a-tetradecahydro-4-hydroxy-α,α,4a,12b,12c-pentamethyl-1-benzopyrano[5′,6′:6,7]indeno[1,2-b]isobenzofuro[5,6-e]indole-2-methanol, 1′α-Hydroxy-paspaline, FO 2546L
• Empirical Formula (Hill Notation): C₂₈H₃₉NO₃
• CAS Number: 167427-23-8
• Molecular Weight: 437.61
• UNSPSC Code: 12352202
• PubChem Substance ID: 329825665
• NACRES: NA.77

Properties

• biological source: Albophoma yamanashiensis
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: −20°C
• SMILES string: OC(C)(C)[C@H]1O[C@@]2([H])CC[C@]3(C)[C@]4(C)[C@@](CC5=C4NC6=C5C=CC=C6)([H])CCC3[C@]2(C)[C@H](O)C1
• InChI: 1S/C28H39NO3/c1-25(2,31)23-15-21(30)27(4)20-11-10-16-14-18-17-8-6-7-9-19(17)29-24(18)28(16,5)26(20,3)13-12-22(27)32-23/h6-9,16,20-23,29-31H,10-15H2,1-5H3/t16-,20?,21+,22-,23-,26-,27+,28+/m0/s1
• InChI key: SVYIMXYKHRBHSG-CDIJYFRTSA-N

Description

Biochem/physiol Actions

Terpendole E is a mitotic kinesin Eg5 (Kinesin-5) inhibitor isolated from Albophoma yamanashiensis that inhibits both motor and microtubule stimulated ATPase activities of human Eg5. Studies indicate that Terpendole E inhibits Eg5 mutants resistant to S-trityl-L-cysteine and other Eg5 inhibitors. Also, Terpendole E is an ACAT (Acyl-CoA:cholesterol acyltransferase) inhibitor.

Terpendole E is a mitotic kinesin Eg5 (Kinesin-5) inhibitor.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable