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SML1116

Sigma-Aldrich

PQ-10

≥98% (HPLC)

Synonym(s):

6,7-Dimethoxy-4-[(3R)-3-(2-quinoxalinyloxy)-1-pyrrolidinyl]-quinazoline, PQ 10

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25 MG
$332.00

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25 MG
$332.00

About This Item

Empirical Formula (Hill Notation):
C22H21N5O3
CAS Number:
927691-21-2
Molecular Weight:
403.43
MDL number:
MFCD12828216
UNSPSC Code:
41106305
PubChem Substance ID:
329825657
NACRES:
NA.77

$332.00

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Request a Bulk Order

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

COC1=CC2=C(N3C[C@H](OC4=CN=C(C=CC=C5)C5=N4)CC3)N=CN=C2C=C1OC

InChI

1S/C22H21N5O3/c1-28-19-9-15-18(10-20(19)29-2)24-13-25-22(15)27-8-7-14(12-27)30-21-11-23-16-5-3-4-6-17(16)26-21/h3-6,9-11,13-14H,7-8,12H2,1-2H3/t14-/m1/s1

InChI key

UBIIFKJMNRPNMT-CQSZACIVSA-N

Biochem/physiol Actions

PQ-10 (6,7-dimethoxy-4-[3-(quinoxalin-2-yloxy)pyrrolidin-1-yl]quinazoline),[1] is capable of suppressing tumor cell growth.[2] It can also reverse the RO-4-1284-induced sedation and catalepsy.[1]
PQ-10 is a potent and selective inhibitor of phosphodiesterase 10A (PDE10).
PQ-10 is a potent and selective inhibitor of phosphodiesterase 10A (PDE10). Apparently, PQ-10 enhances basic auditory information processing in rats. PQ-10 as other PED10 inhibitors suppresses a growth of human non-small cell lung cancer (NSCLC) cell lines.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
084M4719V

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PDE 10A inhibitors stimulate or suppress motor behavior dependent on the relative activation state of the direct and indirect striatal output pathways
Megens AAHP, et al.
Pharmacology Research & Perspectives, 2(4), e00057-e00057 (2014)
Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and beta-catenin-dependent TCF transcriptional activity
Li N, et al.
Oncogene, 34(12), 1499-1499 (2015)
D Santos-García et al.
Journal of the neurological sciences, 418, 117109-117109 (2020-09-15)
The role of subthreshold depression (subD) in Parkinson's Disease (PD) is not clear. The present study aimed to compare the quality of life (QoL) in PD patients with subD vs patients with no depressive disorder (nonD). Factors related to subD

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