SML1080

BRD7116

≥98% (HPLC)

• Synonym(s): 2,2,3,3-Tetramethyl-N-[4-[4-[(2,2,3,3-tetramethylcyclopropanecarbonyl)amino]phenyl]sulfonylphenyl]cyclopropane-1-carboxamide, N,N′-(Sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethyl-cyclopropanecarboxamide
• Empirical Formula (Hill Notation): C₂₈H₃₆N₂O₄S
• CAS Number: 329059-55-4
• Molecular Weight: 496.66
• MDL number: MFCD02168947
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825459
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CC(C1C(NC(C=C2)=CC=C2S(C3=CC=C(NC(C4C(C)(C(C)4C)C)=O)C=C3)(=O)=O)=O)(C(C)1C)C
• InChI: 1S/C28H36N2O4S/c1-25(2)21(26(25,3)4)23(31)29-17-9-13-19(14-10-17)35(33,34)20-15-11-18(12-16-20)30-24(32)22-27(5,6)28(22,7)8/h9-16,21-22H,1-8H3,(H,29,31)(H,30,32)
• InChI key: UHXFWAHRAMUDLJ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

BRD7116 is a selective inhibitor of leukemia stem cells.

BRD7116 is a selective inhibitor of leukemia stem cells. BRD7116 had an EC₅₀ of 200 nM for the leukemia stem cell (LSC)-enriched fraction of cells isolated from the bone marrow of leukemic animals in co-culture compared to ~50% inhibition at 20 μM against normal hematopoietic stem and progenitor cells (HSPCs) and AML cell lines. BRD7116 selectively targeted LSCe cells by cell-autonomous and cell-non-autonomous mechanisms. The exact mechanism is not known, but involved in impairing of the stroma′s ability to support leukemia cells, and inducing transcriptional changes consistent with myeloid differentiation.

Features and Benefits

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Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable