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SML1068

Sigma-Aldrich

TIC10 angular

≥98% (HPLC)

Synonym(s):

7-Benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one., ONC-201, ONC201, TIC10 corrected

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5 MG
$144.00
25 MG
$579.00

About This Item

Empirical Formula (Hill Notation):
C24H26N4O
Molecular Weight:
386.49
UNSPSC Code:
12352200
NACRES:
NA.77

$144.00

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear

storage temp.

2-8°C

General description

TIC10 (TRAIL-inducing compound 10) is an anticancer molecule also referred as ONC201.[1]

Biochem/physiol Actions

TIC10 (TRAIL-inducing compound 10) induces apoptosis mediated by TRAIL (TNF-related apoptosis-inducing ligand) in a number of cancers without toxicity such as breast, colon and glioblastoma multiforme tumors.[2]
TIC10 angular is a potent blood brain barrier penetrant and orally active inducer of TRAIL production that induces death of multiple human cancers.
TIC10 angular is a potent blood brain barrier penetrant and orally active inducer of TRAIL production that induces death of multiple human cancers. TIC10 angular inactivates both Akt and ERK, which results in Foxo3a nuclear factor migration to the nucleus and binding to TRAIL promoter.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
064M4623V

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Small molecule ONC201/TIC10 targets chemotherapy-resistant colorectal cancer stem-like cells in an Akt/Foxo3a/TRAIL-dependent manner.
Varun V P, et al.
Cancer Research, 75(7), 1423-1432 (2015)
Jeremy R E
NMR in Pharmaceutical Science, 185-185 (2015)

Articles

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Questions

1–2 of 2 Questions  

  1. How long can I store a working solution in dimethylsulfoxide (DMSO) at −20°C?

    1 answer

    1. A working solution in dimethylsulfoxide (DMSO) can be stored at ?20°C.

      Note to UGCMB: Please send directly to customer, duplicate

      Helpful?

  2. What is storage temperature for 100 mM TIC10 in DMSO? 4 degrees or -20 degree?

    1 answer

    1. A working solution in dimethylsulfoxide (DMSO) can be stored at −20°C.

      Helpful?

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