SML1054

SBI-0087702

≥98% (HPLC)

• Synonym(s): 4-Methoxy-N-[2-(4-methoxyphenyl)ethyl]-1-naphthalenemethanamine
• Empirical Formula (Hill Notation): C₂₁H₂₃NO₂
• CAS Number: 864431-36-7
• Molecular Weight: 321.41
• MDL number: MFCD01135860
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825640
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: white to light brown
• solubility: DMSO: 5 mg/mL, clear (warmed)
• Storage temp.: room temp
• SMILES string: COC1=C2C(C=CC=C2)=C(CNCCC3=CC=C(OC)C=C3)C=C1
• InChI: 1S/C21H23NO2/c1-23-18-10-7-16(8-11-18)13-14-22-15-17-9-12-21(24-2)20-6-4-3-5-19(17)20/h3-12,22H,13-15H2,1-2H3
• Inchi Key: SNBZXHDTILHVJS-UHFFFAOYSA-N

Description

Biochem/physiol Actions

SBI-0087702 promotes the cytoplasmic localization of ATF2 in melanoma cells. SBI-0087702-induced translocation of ATF2 to the mitochondria results in increased apoptosis due to loss of mitochondrial membrane integrity. SBI-0087702 also inhibits growth and motility of melanoma cells. SBI-0087702 was shown to inhibit ATF2 phosphorylation on Thr52 by PKCε.

SBI-0087702 promotes the cytoplasmic localization of ATF2, which induces apoptosis and inhibits growth and motility of melanoma cells.

Features and Benefits

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Safety Information

• Pictograms: GHS05,GHS09
• signalword: Danger
• hcodes: H318,H410
• pcodes: P273 - P280 - P305 + P351 + P338 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1
• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable