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Key Documents

SML1033

Sigma-Aldrich

A-278637

≥98%

Synonym(s):

(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydro-thieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide

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25 MG
$251.00

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25 MG
$251.00

About This Item

Empirical Formula (Hill Notation):
C17H15BrFNO3S
CAS Number:
Molecular Weight:
412.27
UNSPSC Code:
12352202
NACRES:
NA.77

$251.00


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Quality Level

assay

≥98%

form

powder

optical activity

[α]/D -44 to -54°, c = 0.1 in acetonitrile

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

A-278637 is a selective opener of ATP-sensitive K (KATP) channels (EC50 = 102 nM) that blocks contraction of bladder smooth muscle in both in vivo and in vitro assays. A-278637 is 15-fold more selective than nifedipine for bladder compared other smooth muscle KATP channels, and displays reduced effects on mean arterial pressure compared to other channel openers.
A-278637 is a selective opener of ATP-sensitive K (KATP) channels.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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