SML1030
HENA
≥98% (HPLC)
Synonym(s):
(3b,20b)-3-Hydroxy-olean-12-en-29-oic acid sodium salt
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About This Item
Empirical Formula (Hill Notation):
C30H47NaO3
CAS Number:
Molecular Weight:
478.68
UNSPSC Code:
12352200
NACRES:
NA.77
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 3 mg/mL, clear (warmed)
Storage temp.
room temp
General description
Biochem/physiol Actions
HENA (3-Hydroxyolean-12-en-30-oate) specifically activates large conductance, voltage- and Ca2+-gated K+ (BK) channels containing KCNMB1 (β1) subunits (EC50 = 53 μM). BK/β1 channels are expressed predominantly in smooth muscle. HENA induces vasodilation in rodent models.
HENA ia a β1 subunit-selective Ca2+ / voltage-gated K+ (BK) channel activator.
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Find documentation for the products that you have recently purchased in the Document Library.
Multi-generational pharmacophore modeling for ligands to the cholane steroid-recognition site in the ?1 modulatory subunit of the BKCa channel.
McMillan J E, et al.
Journal of Molecular Graphics & Modelling, 54, 174-183 (2014)
Competitive Interactions of Kv7 Channel Carboxy-Termini with PIP2 and Calmodulin.
Kirton H M
Biophysical Journal, 102(3), 133a-133a (2012)
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