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Key Documents

SML1029

Sigma-Aldrich

KP372-1

≥98% (HPLC)

Synonym(s):

10H-Indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one (1:1), 6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one

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About This Item

Empirical Formula (Hill Notation):
C10H4N6O
CAS Number:
Molecular Weight:
224.18
UNSPSC Code:
12352200
NACRES:
NA.77

description

1:1 mixture of two isomers

assay

≥98% (HPLC)

form

powder

color

light yellow to dark yellow

solubility

DMSO: 10 mg/mL, clear

Storage temp.

2-8°C

Biochem/physiol Actions

KP372-1 is a potent inhibitor of AKT and PKD.
KP372-1 is a potent inhibitor of AKT and PKD. KP-372-1 blocks PI3K/AKT/mTOR signaling pathways, and induces apoptosis in leukemia cell lines and primary tumor cells from patients with AML.

Pictograms

Flame

signalword

Danger

hcodes

Hazard Classifications

Self-react. C

Storage Class

5.2 - Organic peroxides and self-reacting hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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