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SML1012

Sigma-Aldrich

MN-64

≥98% (HPLC)

Synonym(s):

2-[4-(1-Methylethyl)phenyl]-4H-1-benzopyran-4-one

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About This Item

Empirical Formula (Hill Notation):
C18H16O2
CAS Number:
92831-11-3
Molecular Weight:
264.32
MDL number:
MFCD00829158
UNSPSC Code:
12352200
PubChem Substance ID:
329825630
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C1C2=CC=CC=C2OC(C3=CC=C(C(C)C)C=C3)=C1

InChI

1S/C18H16O2/c1-12(2)13-7-9-14(10-8-13)18-11-16(19)15-5-3-4-6-17(15)20-18/h3-12H,1-2H3

InChI key

PYTOHIUBXSJKQH-UHFFFAOYSA-N

Biochem/physiol Actions

MN-64 is a very potent inhibitor of Tankyrase 1 and 2 (IC50 = 6 and 72 nM, respectively). The compound MN-64 blocks Wnt signaling in HEK293 cells containing a Wnt pathway reporter system.
MN-64 is a very potent inhibitor of Tankyrase 1 and 2.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
084M4718V

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Sukyeong Kim et al.
Nature communications, 10(1), 4898-4898 (2019-10-28)
Osteoarthritis (OA) is a prevalent degenerative disease, which involves progressive and irreversible destruction of cartilage matrix. Despite efforts to reconstruct cartilage matrix in osteoarthritic joints, it has been a difficult task as adult cartilage exhibits marginal repair capacity. Here we

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Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

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